Group Leader / Sr Group Leader - Medicinal Chemistry

Employment Type

: Full-Time


: Miscellaneous

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The Broad Institute is a unique place for drug discovery - we exist to apply our deep knowledge of human genetics to empower a revolution in biomedicine and accelerate the pace at which the world conquers disease. The Broad Institute’s Center for the Development of Therapeutics (CDoT) (‘Biotech within Broad’) and its team of professional “drug hunters” partner with faculty at MIT, Harvard and the Harvard teaching hospitals to translate emerging biological insights into novel therapeutic strategies. We couple novel technologies and approaches to industry-standard drug discovery rigor to tackle some of the most challenging targets across a wide range of disease areas (including oncology, cardiovascular disease, diabetes, psychiatric disease and infectious disease).

We are looking for a highly motivated scientist to lead and mentor a team of medicinal chemists focused on discovering novel small molecule therapeutics across a diverse disease portfolio. The successful candidate will join The Center for the Development of Therapeutics and lead a team of professional scientists at the interface of industry and academia. The candidate will work closely with biochemists, structural and biophysical scientists, cell biologists and pharmacologists, to rapidly progress therapeutic projects in partnership with academic scientists and industrial partners. The successful applicant will have the unique opportunity to impact both the strategy and execution of multiple therapeutic programs driven by the novel genetic and biological insights being discovered at the Broad Institute.


  • Ph.D. in synthetic/medicinal chemistry with 8+ years of research experience in an industrial setting managing a team of professional chemists, including contract research chemists.
  • Must have demonstrated track record of successfully moving drug discovery programs through a full life cycle from screening through development to clinical candidate as project/chemistry team leader.
  • Demonstrated leadership by implementing medicinal chemistry strategies across all stages of drug discovery from hit identification, through lead optimization to clinical candidate selection.
  • Deep experience leading multi-disciplinary teams and utilizing cross-functional data to drive drug discovery strategies in a matrix organization environment.
  • Strong experience in oncology and/or cardiovascular drug discovery preferred
  • Significant experience in cutting-edge synthetic chemistry, with evidence of creative solutions to complex synthesis problems.
  • Experience managing and integrating internal resources with external commercial collaborators and contract research organizations to achieve project goals in a timely and cost effective manner.
  • Must have strong interpersonal and communication skills

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