Scientist ( Analytical Chemistry )

Compensation

: $98,760.00 - $143,170.00 /year *

Employment Type

: Full-Time

Industry

: Scientific Research



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Position Summary Known for its scientific and operational excellence, Regeneron is a leading science-based biopharmaceutical company that discovers, invents, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions. Regeneron commercializes medicines for eye diseases, high LDL-cholesterol, atopic dermatitis and a rare inflammatory condition and has product candidates in development in other areas of high unmet medical need, including rheumatoid arthritis, asthma, pain, cancer and infectious diseases. Summary We are seeking highly motivated scientist candidates with Ph.D. degrees to join the Analytical Chemistry Group of Regeneron Pharmaceutical Inc. located at Tarrytown, NY. The successful candidate will be working in a state-of-the-art mass spectrometry lab, and developing top-down and bottom-up mass spectrometry analytical methods for therapeutic protein product analysis. The individual will lead the efforts on the biochemical characterization of therapeutic protein at all stages of development, providing high quality analytical characterization data for regulatory submissions. The individual will also lead the activities of developing innovative mass spectrometry technologies to support Regeneron's upstream R&D programs. Responsibilities oLeads the development activities with a focus on developing top-down and/or bottom-up mass spectrometry analytical methods to support the characterization of therapeutic protein drug candidates. oServes as a team representative in drug candidate-specific development team meetings, and shares knowledge and expertise of analytics development at cross-functional team meetings. Independently designs and conducts analytical experiments on therapeutic proteins characterization and analyzes mass spectrometry data to elucidate the quality attributes of therapeutic protein candidates and/or products; conducts analytical methods qualification to support the late-stage therapeutic protein development programs. Documents experiments, results and findings in electronic laboratory notebook; presents work at the group and department meetings; drafts SOPs, memos, development reports, and regulatory submission documents and peer-reviewed articles for publications. oProvides analytical support for both upstream and downstream functional groups and helps to solve real-time development problems. oMay directly or indirectly lead, guide, and assist Research Associates in conducting research and developmental work, investigating and solving developmental problems. Sets goals, assigns tasks, provides performance management and development as needed. oParticipates in the general lab and instrument maintenance. Requirements oPhD in chemistry, or biochemistry or proteomics with 0-2 years post-doctoral training in a mass spectrometry-oriented lab, and with proven track record of publications in the field. oExpertise in mass spectrometry principles and applications for protein characterization, with keen analytical and problem-solving skills. Extensive hand-on experiences and trouble-shooting proficiency on separation science and mass spectrometry technologies, including Orbitrap MS (e.g. Q Exactive), Q-TOF and/or triple-quadruple MS systems. oExperience in glycomics, glycoproteomics or LC-MS/MS methods of analyzing PK/PD profiles for antibody therapeutic candidates is a plus. oProficiency in mass spectrometry related software, such as Xcalibur, MassLynx, Skyline, MassHunter, Proteome Discoverer, Mascot, Empower, etc. Abilities in computer programming a plus. oExcellent oral and written communication skills are required. oEnthusiasm in science with a motivation of making contributions in a team environment.Salary Range: NAMinimum QualificationLess than 5 years
Associated topics: chemical, coatings, nutrition, pha, phenolic, plastics, polymer, polymer synthesis, polypropylene, polyurethane * The salary listed in the header is an estimate based on salary data for similar jobs in the same area. Salary or compensation data found in the job description is accurate.

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