Scientist - Immunology/Inflammation Target Discovery and Validation -

Compensation

: $87,420.00 - $133,750.00 /year *

Employment Type

: Full-Time

Industry

: Healthcare - Physician



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Known for its scientific and operational excellence, Regeneron is a leading science-based biopharmaceutical company that discovers, invents, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions. Regeneron commercializes medicines for eye diseases, high LDL-cholesterol, atopic dermatitis and a rare inflammatory condition and has product candidates in development in other areas of high unmet medical need, including rheumatoid arthritis, asthma, pain, cancer and infectious diseases.

Summary:
This position within the Immunology and Inflammation Area is for a rigorous scientist with preferred experience in autoimmunity and/or allergy, B cell biology and disease models driven by pathogenic antibodies. Candidate should be highly collaborative and team-driven, possess exceptional organizational skills and be capable of independently conducting in vitro and in vivo experiments. This individual will have the opportunity to support a broad pipeline in autoimmune and inflammatory diseases by validating targets, assessing the efficacy of therapeutic candidate molecules in disease models, and interrogating mechanisms of pathology that inform therapeutic strategies.

Responsibilities:

Contribute to project advancement by developing new methods and technologies

Troubleshoots methodological and technical issues, interprets experimental data and literature, and communicates results to supervisor, department, or project team.

Executes experiments based on projects/protocols provided and works towards independently developing project

Collaborates and communicates efficiently with team members to coordinate complex in vivo experiments, and with other departments to facilitate cross-functional efforts

Experience with proper handling and care of mice, general surgical techniques and the collection of blood and tissue samples.

Develops and optimizes relevant disease mouse models and the subsequent analysis of associated disease-related pathologies by flow cytometry, histology and ELISA

Develops and executes cell based assays to screen candidate antibodies for various research programs

Performs ELISAs and or MSDs to measure cytokine levels and determine antigen binding for various research programs

Extensive experience with multi-parameter Flow cytometry and data analysis is required. Candidate will present analyzed data to supervisor and team.

Basic computer literacy and experience collecting and analyzing biological data on the computer is a necessity.

Contribute to lab and equipment maintenance and order supplies/reagents to help create a safe, effective and efficient working environment.

Requirements:
Qualified applicants will have a Ph.D. in Biology, Immunology, or Cellular and Molecular Biology and at least 3-5 year of academic or 2-4 years of industry post doc experience in immunology

The ideal candidate will be skilled in the design of complex studies to interrogate the in vivo efficacy of novel therapeutics and thus, will have experience with developing and optimizing mouse models of autoimmune and/or allergic diseases and the subsequent analysis of associated disease-related pathologies by flow cytomety, histology and ELISA.

Knowledge of autoimmune and allergic diseases, B-cell and plasma cell biology is preferred

Must have experience conducting studies utilizing flow cytometry as well as the design of panels, analysis of data and interpretation of findings.

Preferred experience developing and optimizing primary cell assays used to characterize cytokine and immunoreceptor pathways and screen antibody candidates is preferred.

Preferred experience with the following data analysis programs:
GraphPad PRISM, Softmax Pro, FlowJo analysis, HALO, DIVA software

Must have a record of high quality publications in scientific literature.

The candidate is expected to have effective oral communication and written skills.

To all agencies: Please, no phone calls or emails to any employee of Regeneron about this opening. All resumes submitted by search firms/employment agencies to any employee at Regeneron via-email, the internet or in any form and/or method will be deemed the sole property of Regeneron, unless such search firms/employment agencies were engaged by Regeneron for this position and a valid agreement with Regeneron is in place. In the event a candidate who was submitted outside of the Regeneron agency engagement process is hired, no fee or payment of any kind will be paid.

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.
Associated topics: amp, anatomic, companion, diagnostics, forensic, investigative, lab, laboratory, molecular, research * The salary listed in the header is an estimate based on salary data for similar jobs in the same area. Salary or compensation data found in the job description is accurate.

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